InnateDB Protein
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IDBP-33267.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DKK2
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Protein Name
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dickkopf homolog 2 (Xenopus laevis)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000285311
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InnateDB Gene
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IDBG-33265 (DKK2)
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Protein Structure
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Function |
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Expressed in heart, brain, skeletal muscle and lung.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0008270
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zinc ion binding
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Biological Process |
GO:0006355
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regulation of transcription, DNA-templated
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GO:0007275
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multicellular organismal development
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GO:0016055
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Wnt signaling pathway
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GO:0030178
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negative regulation of Wnt signaling pathway
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GO:0090090
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negative regulation of canonical Wnt signaling pathway
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GO:0090263
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positive regulation of canonical Wnt signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR001138
Zn(2)-C6 fungal-type DNA-binding domain
IPR006796
Dickkopf, N-terminal cysteine-rich
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PFAM |
PF00172
PF04706
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PRINTS |
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PIRSF |
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SMART |
SM00066
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UBU2
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PhosphoSite |
PhosphoSite-Q9UBU2
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TrEMBL |
D6RGF1
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UniProt Splice Variant |
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Entrez Gene |
27123
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UniGene |
Hs.581804
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RefSeq |
NP_055236
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HUGO |
HGNC:2892
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OMIM |
605415
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CCDS |
CCDS3675
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HPRD |
05658
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IMGT |
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EMBL |
AB033208
AB035181
AC003099
AC104663
AC106863
AF177395
AK312695
AP001819
AY358414
BC075077
BC075078
BC126328
BC126330
CH471057
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GenPept |
AAF02675
AAH75077
AAH75078
AAI26329
AAI26331
AAQ88780
BAA85465
BAA87056
BAG35574
EAX06209
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