InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SETDB2

Summary

InnateDB Protein

IDBP-33321.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SETDB2

Protein Name

SET domain, bifurcated 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000346175

InnateDB Gene

IDBG-33315 (SETDB2)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. {ECO:0000269PubMed:20404330}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20404330}. Chromosome {ECO:0000305PubMed:20404330}.

Disease Associations

Tissue Specificity

Ubiquitous. Highest expression in heart, testis and ovary.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0046974	histone methyltransferase activity (H3-K9 specific)

Biological Process

GO:0001947	heart looping
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0034968	histone lysine methylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051567	histone H3-K9 methylation
GO:0070986	left/right axis specification