InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLR2C

Summary

InnateDB Protein

IDBP-33329.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLR2C

Protein Name

polymerase (RNA) II (DNA directed) polypeptide C, 33kDa

Synonyms

hRPB33; hsRPB3; RPB3; RPB31;

Species

Homo sapiens

Ensembl Protein

ENSP00000219252

InnateDB Gene

IDBG-33327 (POLR2C)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9852112}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 120 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	120 [view]
Protein-Protein	118 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001055	RNA polymerase II activity
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006351	transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006370	7-methylguanosine mRNA capping
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016032	viral process
GO:0050434	positive regulation of viral transcription

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005665	DNA-directed RNA polymerase II, core complex
GO:0005737	cytoplasm
GO:0015630	microtubule cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR009025 DNA-directed RNA polymerase, RBP11-like dimerisation domain
IPR011262 DNA-directed RNA polymerase, insert domain
IPR011263 DNA-directed RNA polymerase, RpoA/D/Rpb3-type

PFAM

PF01193
PF01000

PRINTS

PIRSF

SMART

SM00662

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P19387