Version 5.4
Homo sapiens Protein: BIN2
Summary
InnateDB Protein IDBP-33349.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BIN2
Protein Name bridging integrator 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000267012
InnateDB Gene IDBG-33347 (BIN2)
Protein Structure
UniProt Annotation
Function Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269PubMed:23285027}.
Subcellular Localization Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cell projection, phagocytic cup. Note=Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure.
Disease Associations
Tissue Specificity Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues. {ECO:0000269PubMed:10903846, ECO:0000269PubMed:23285027}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
Biological Process
GO:0006911 phagocytosis, engulfment
GO:0060326 cell chemotaxis
GO:0071800 podosome assembly
GO:0097320 membrane tubulation
Cellular Component
GO:0001891 phagocytic cup
GO:0002102 podosome
GO:0005737 cytoplasm
GO:0005938 cell cortex
GO:0030054 cell junction
GO:0042995 cell projection
Protein Structure and Domains
PDB ID
InterPro IPR003005 Amphiphysin
IPR004148 BAR domain
PFAM PF03114
PRINTS PR01251
PIRSF
SMART SM00721
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBW5
PhosphoSite PhosphoSite-Q9UBW5
TrEMBL
UniProt Splice Variant
Entrez Gene 51411
UniGene
RefSeq NP_057377
HUGO HGNC:1053
OMIM 605936
CCDS CCDS8811
HPRD 05805
IMGT
EMBL AB032698 AB032710 AC046135 AF146531 AK000783 BC047686
GenPept AAD54227 AAH47686 BAA88108 BAA88125 BAA91376

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca