InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CELA1

Summary

InnateDB Protein

IDBP-33381.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CELA1

Protein Name

chymotrypsin-like elastase family, member 1

Synonyms

ELA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000293636

InnateDB Gene

IDBG-33379 (CELA1)

Protein Structure

UniProt Annotation

Function

Acts upon elastin.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Basal layers of epidermis (at protein level). Not expressed in the pancreas. {ECO:0000269PubMed:10620133}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006508	proteolysis
GO:0006954	inflammatory response
GO:0009791	post-embryonic development
GO:0016055	Wnt signaling pathway
GO:0031017	exocrine pancreas development
GO:0035264	multicellular organism growth
GO:0042127	regulation of cell proliferation
GO:0045595	regulation of cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0055123	digestive system development
GO:0061113	pancreas morphogenesis