Version 5.4
Homo sapiens Protein: PHF11
Summary
InnateDB Protein IDBP-33456.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHF11
Protein Name PHD finger protein 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367570
InnateDB Gene IDBG-33454 (PHF11)
Protein Structure
UniProt Annotation
Function Positive regulator of Th1-type cytokine gene expression. {ECO:0000269PubMed:18405956}.
Subcellular Localization Nucleus {ECO:0000269PubMed:18405956}.
Disease Associations
Tissue Specificity Highly expressed in T and B-cells, as well as natural killer and mature dendritic cells. Expressed at higher levels in Th1 as compared to Th2 cells. Expressed at low levels in all normal tissues tested, including lung, testis, small intestine, breast, liver and placenta. {ECO:0000269PubMed:18405956}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001965 Zinc finger, PHD-type
IPR011011 Zinc finger, FYVE/PHD-type
PFAM
PRINTS
PIRSF
SMART SM00249
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UIL8
PhosphoSite PhosphoSite-Q9UIL8
TrEMBL X6RH80
UniProt Splice Variant
Entrez Gene 51131
UniGene Hs.369039
RefSeq NP_001035533
HUGO HGNC:17024
OMIM 607796
CCDS CCDS31975
HPRD
IMGT
EMBL AB011031 AF155105 AL139321 BC017212 CH471075
GenPept AAD42871 AAH17212 BAA32101 CAH71044 CAH71046 EAX08828

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca