Homo sapiens Protein: SLC4A8 | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||
InnateDB Protein | IDBP-33466.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | SLC4A8 | ||||||||||||||||||
Protein Name | solute carrier family 4, sodium bicarbonate cotransporter, member 8 | ||||||||||||||||||
Synonyms | NBC3; NDCBE; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000351483 | ||||||||||||||||||
InnateDB Gene | IDBG-33464 (SLC4A8) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. {ECO:0000269PubMed:10362779, ECO:0000269PubMed:11133997}. | ||||||||||||||||||
Subcellular Localization | Membrane {ECO:0000269PubMed:17715183}; Multi-pass membrane protein {ECO:0000269PubMed:17715183}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex. {ECO:0000269PubMed:10362779, ECO:0000269PubMed:11133997, ECO:0000269PubMed:17715183}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
|
||||||||||||||||||
Gene Ontology | |||||||||||||||||||
Molecular Function |
|
||||||||||||||||||
Biological Process |
|
||||||||||||||||||
Cellular Component |
|
||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR003020
Bicarbonate transporter, eukaryotic IPR003024 Sodium bicarbonate cotransporter IPR011531 Bicarbonate transporter, C-terminal IPR013769 Band 3 cytoplasmic domain IPR016152 Phosphotransferase/anion transporter |
||||||||||||||||||
PFAM |
PF00955
PF07565 |
||||||||||||||||||
PRINTS |
PR01231
PR01232 |
||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q2Y0W8 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q2Y0W8 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 9498 | ||||||||||||||||||
UniGene | Hs.4749 | ||||||||||||||||||
RefSeq | NP_001245330 | ||||||||||||||||||
HUGO | HGNC:11034 | ||||||||||||||||||
OMIM | 605024 | ||||||||||||||||||
CCDS | CCDS73470 | ||||||||||||||||||
HPRD | 05430 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB018282 AC025097 AC046135 AC107031 AF069512 AF107099 AK295315 AL831915 BC025994 CH471111 DQ063579 DQ975204 DQ996398 DQ996537 | ||||||||||||||||||
GenPept | AAC82380 AAD52981 AAH25994 AAY79176 ABJ09587 ABJ91576 ABJ91577 BAA34459 BAG58292 CAD38576 EAW58192 | ||||||||||||||||||