InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNAJB1

Summary

InnateDB Protein

IDBP-33493.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAJB1

Protein Name

DnaJ (Hsp40) homolog, subfamily B, member 1

Synonyms

Hdj1; Hsp40; HSPF1; RSPH16B; Sis1;

Species

Homo sapiens

Ensembl Protein

ENSP00000254322

InnateDB Gene

IDBG-33491 (DNAJB1)

Protein Structure

UniProt Annotation

Function

Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:1586970}. Nucleus {ECO:0000269PubMed:1586970}. Nucleus, nucleolus {ECO:0000269PubMed:1586970}. Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	77 [view]
Protein-Protein	74 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001671	ATPase activator activity
GO:0005515	protein binding
GO:0030544	Hsp70 protein binding
GO:0051082	unfolded protein binding
GO:0051087	chaperone binding
GO:0051117	ATPase binding

Biological Process

GO:0006457	protein folding
GO:0006986	response to unfolded protein
GO:0032781	positive regulation of ATPase activity
GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0070389	chaperone cofactor-dependent protein refolding
GO:0090084	negative regulation of inclusion body assembly