InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYO15A

Summary

InnateDB Protein

IDBP-33541.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO15A

Protein Name

myosin XVA

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000205890

InnateDB Gene

IDBG-33539 (MYO15A)

Protein Structure

UniProt Annotation

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity). {ECO:0000250}.

Subcellular Localization

Cell projection, stereocilium {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localizes to stereocilium tips in cochlear and vestibular hair cells. {ECO:0000250}.

Disease Associations

Deafness, autosomal recessive, 3 (DFNB3) [MIM:600316]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269PubMed:11735029, ECO:0000269PubMed:9603736}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in pituitary. Also expressed at lower levels in adult brain, kidney, liver, lung, pancreas, placenta and skeletal muscle. Not expressed in brain. In the pituitary, highly expressed in anterior gland cells. {ECO:0000269PubMed:10552926}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding

Biological Process

GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0008152	metabolic process
GO:0042472	inner ear morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0016459	myosin complex
GO:0032420	stereocilium
GO:0032421	stereocilium bundle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000299 FERM domain
IPR000857 MyTH4 domain
IPR001452 SH3 domain
IPR001609 Myosin head, motor domain
IPR011511 Variant SH3 domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029071 Ubiquitin-related domain

PFAM