InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EMR3

Summary

InnateDB Protein

IDBP-33596.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EMR3

Protein Name

egf-like module containing, mucin-like, hormone receptor-like 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000340758

InnateDB Gene

IDBG-33590 (EMR3)

Protein Structure

UniProt Annotation

Function

Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes- derived macrophages and activated neutrophils.

Subcellular Localization

EGF-like module-containing mucin-like hormone receptor-like 3: Cell membrane; Multi-pass membrane protein.EGF-like module-containing mucin-like hormone receptor-like 3 subunit beta: Cell membrane; Multi-pass membrane protein.EGF-like module-containing mucin-like hormone receptor-like 3 subunit alpha: Secreted, extracellular space. Note=A soluble form is also detected (alpha subunit).Isoform 3: Secreted.

Disease Associations

Tissue Specificity

Displays a predominantly leukocyte-restricted expression, with highest levels in neutrophils, monocytes and macrophages.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005639	integral component of nuclear inner membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000203 GPS motif
IPR000832 GPCR, family 2, secretin-like
IPR001740 GPCR, family 2, EMR1 hormone receptor
IPR017981 GPCR, family 2-like
IPR018996 Inner nuclear membrane protein MAN1

PFAM

PF01825
PF00002
PF09402

PRINTS

PR00249
PR01128

PIRSF

SMART

SM00303

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt