Homo sapiens Protein: ARL11
Summary
InnateDB Protein IDBP-33689.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARL11
Protein Name ADP-ribosylation factor-like 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000282026
InnateDB Gene IDBG-33687 (ARL11)
Protein Structure
UniProt Annotation
Function May play a role in apoptosis. May act as a tumor suppressor. {ECO:0000269PubMed:15843669}.
Subcellular Localization
Disease Associations Leukemia, chronic lymphocytic (CLL) [MIM:151400]: A chronic leukemia in which functionally incompetent B-lymphocytes progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Tissue Specificity Expressed in lung and leukocytes. {ECO:0000269PubMed:15843669}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006886 intracellular protein transport
GO:0007264 small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001806 Small GTPase superfamily
IPR005225 Small GTP-binding protein domain
IPR006687 Small GTPase superfamily, SAR1-type
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00071
PF00025
PF04670
PF08477
PF09439
PRINTS PR00449
PR00328
PIRSF
SMART SM00178
SM00177
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q969Q4
PhosphoSite PhosphoSite-Q969Q4
TrEMBL
UniProt Splice Variant
Entrez Gene 115761
UniGene Hs.558599
RefSeq NP_612459
HUGO HGNC:24046
OMIM 609351
CCDS CCDS9419
HPRD 12484
IMGT
EMBL AF441378 AK091249 AL135901 BC013150
GenPept AAH13150 AAP19650 BAC03621 CAI40715