InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRKAR2A

Summary

InnateDB Protein

IDBP-33725.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKAR2A

Protein Name

protein kinase, cAMP-dependent, regulatory, type II, alpha

Synonyms

PKR2; PRKAR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000265563

InnateDB Gene

IDBG-33721 (PRKAR2A)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21423175}. Cell membrane {ECO:0000269PubMed:21423175}. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane.

Disease Associations

Tissue Specificity

Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	55 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004862	cAMP-dependent protein kinase inhibitor activity
GO:0005515	protein binding
GO:0008603	cAMP-dependent protein kinase regulator activity
GO:0030552	cAMP binding
GO:0031625	ubiquitin protein ligase binding
GO:0034236	protein kinase A catalytic subunit binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0006112	energy reserve metabolic process
GO:0006833	water transport
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007596	blood coagulation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0034199	activation of protein kinase A activity
GO:0035556	intracellular signal transduction
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050796	regulation of insulin secretion
GO:0055085	transmembrane transport
GO:0071377	cellular response to glucagon stimulus
GO:2000480	negative regulation of cAMP-dependent protein kinase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005952	cAMP-dependent protein kinase complex
GO:0016020	membrane
GO:0031588	AMP-activated protein kinase complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000595 Cyclic nucleotide-binding domain
IPR002373 cAMP/cGMP-dependent protein kinase
IPR003117 Dimerization-anchoring domain of cAMP-dependent protein kinase, regulatory subunit
IPR012198 cAMP-dependent protein kinase regulatory subunit
IPR018490 Cyclic nucleotide-binding-like

PFAM

PF00027
PF02197

PRINTS

PR00103

PIRSF

PIRSF000548

SMART

SM00100
SM00394

TIGRFAMs

Post-translational Modifications

Modification

Cross-References