InnateDB Protein
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IDBP-33758.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KATNB1
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Protein Name
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katanin p80 (WD repeat containing) subunit B 1
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Synonyms
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KAT;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000368982
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InnateDB Gene
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IDBG-33756 (KATNB1)
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Protein Structure
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Function |
Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255HAMAP-Rule:MF_03022}.
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Subcellular Localization |
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
22
[view]
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Protein-Protein |
22
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
IPR020472
G-protein beta WD-40 repeat
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PFAM |
PF00400
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PRINTS |
PR00320
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BVA0
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PhosphoSite |
PhosphoSite-Q9BVA0
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TrEMBL |
H3BTV8
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UniProt Splice Variant |
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Entrez Gene |
10300
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UniGene |
Hs.275675
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RefSeq |
NP_005877
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HUGO |
HGNC:6217
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OMIM |
602703
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CCDS |
CCDS10788
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HPRD |
04081
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IMGT |
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EMBL |
AC018552
AC092118
AF052432
BC001353
BT007022
CH471092
CR456762
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GenPept |
AAC09328
AAH01353
AAP35668
CAG33043
EAW82951
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