Version 5.4
Homo sapiens Protein: NUCB2
Summary
InnateDB Protein IDBP-33793.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUCB2
Protein Name nucleobindin 2
Synonyms HEL-S-109; NEFA;
Species Homo sapiens
Ensembl Protein ENSP00000320168
InnateDB Gene IDBG-33791 (NUCB2)
Protein Structure
UniProt Annotation
Function Calcium-binding protein. May have a role in calcium homeostasis.Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus {ECO:0000269PubMed:11749975}. Membrane {ECO:0000269PubMed:11749975}; Peripheral membrane protein {ECO:0000269PubMed:11749975}. Cytoplasm {ECO:0000269PubMed:11749975}. Secreted {ECO:0000269PubMed:11749975}. Endoplasmic reticulum {ECO:0000250}. Nucleus envelope {ECO:0000250}. Note=Golgi retention is mediated by its N-terminal region.Nesfatin-1: Secreted.
Disease Associations
Tissue Specificity Predominantly expressed in spleen, testis and normal stomach. {ECO:0000269PubMed:12087473}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
Experimentally validated
Total 30 [view]
Protein-Protein 29 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P80303
PhosphoSite PhosphoSite-P80303
TrEMBL E9PRQ3
UniProt Splice Variant
Entrez Gene 4925
UniGene Hs.654599
RefSeq
HUGO HGNC:8044
OMIM 608020
CCDS
HPRD 09726
IMGT
EMBL AB478625 AC107956 AF052642 AF052643 AF052644 AF450266 AK291507 CH471064 X76732
GenPept AAC06300 AAC06301 AAC06302 AAM73810 BAF84196 BAJ09615 CAA54148 EAW68439 EAW68440

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca