InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCR3LG1

Summary

InnateDB Protein

IDBP-33814.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCR3LG1

Protein Name

B7 homolog 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000341637

InnateDB Gene

IDBG-33812 (NCR3LG1)

Protein Structure

UniProt Annotation

Function

Triggers NCR3-dependent natural killer cell activation. {ECO:0000269PubMed:19528259}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:19528259}; Single-pass type I membrane protein {ECO:0000269PubMed:19528259}.

Disease Associations

Tissue Specificity

Not detected in any normal tissue tested. Expressed at the surface of several tumor cell lines including T and B-lymphomas, myeloid leukemias, melanomas, carcinomas and large T SV40 antigen-transformed cells (at protein level). {ECO:0000269PubMed:19528259}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0019028	viral capsid

Protein Structure and Domains

PDB ID

InterPro

IPR000840 Gamma-retroviral matrix, N-terminal
IPR003597 Immunoglobulin C1-set
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR010999 Retroviral matrix, N-terminal
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF01140
PF07654
PF08205

PRINTS

PIRSF

SMART

SM00407
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q68D85