InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KPNA3

Summary

InnateDB Protein

IDBP-33880.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KPNA3

Protein Name

karyopherin alpha 3 (importin alpha 4)

Synonyms

hSRP1; IPOA4; SRP1; SRP1gamma; SRP4;

Species

Homo sapiens

Ensembl Protein

ENSP00000261667

InnateDB Gene

IDBG-33878 (KPNA3)

Protein Structure

UniProt Annotation

Function

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	50 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008139	nuclear localization sequence binding
GO:0008565	protein transporter activity

Biological Process

GO:0006461	protein complex assembly
GO:0006606	protein import into nucleus
GO:0006607	NLS-bearing protein import into nucleus
GO:0019221	cytokine-mediated signaling pathway
GO:0046718	viral entry into host cell
GO:0075732	viral penetration into host nucleus