InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPATA9

Summary

InnateDB Protein

IDBP-33901.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPATA9

Protein Name

spermatogenesis associated 9

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000274432

InnateDB Gene

IDBG-33899 (SPATA9)

Protein Structure

UniProt Annotation

Function

May play a role in testicular development/spermatogenesis and may be an important factor in male infertility. {ECO:0000269PubMed:12493713}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in testes and pancreas. Low levels found in the heart, lungs, and brain. Very low expression detected in the placenta. No expression seen in skeletal muscle, liver, kidney, thymus, small intestine, colons, spleen, leukocytes, prostate gland, and ovary. In the adult testes, expression was about 6.44-fold higher than in the embryo testes. No expression in testes of patients with Sertoli-cell-only syndrome. In patients with arrest at spermatogonium and primary spermatocyte stages, no expression was detected. In patients with arrest at the spermatid stage, expression level was weak or absent. Variable expression was seen in patients with spermatogenic arrest. {ECO:0000269PubMed:12493713}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process