InnateDB Protein
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IDBP-33914.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TAF2
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Protein Name
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TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
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Synonyms
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CIF150; MRT40; TAF2B; TAFII150;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000367406
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InnateDB Gene
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IDBG-33912 (TAF2)
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Protein Structure
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Function |
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter. {ECO:0000269PubMed:9418870, ECO:0000269PubMed:9774672}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:9774672}.
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Disease Associations |
Mental retardation, autosomal recessive 40 (MRT40) [MIM:615599]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT40 affected individuals also show microcephaly, spasticity, thin corpus callosum, pyramidal signs. {ECO:0000269PubMed:24084144}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed in all tissues tested. {ECO:0000269PubMed:9774672}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
28
[view]
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Protein-Protein |
25
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000086
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G2/M transition of mitotic cell cycle
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0006508
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proteolysis
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GO:0014070
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response to organic cyclic compound
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR014782
Peptidase M1, membrane alanine aminopeptidase, N-terminal
IPR016024
Armadillo-type fold
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PFAM |
PF01433
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PRINTS |
PR00756
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6P1X5
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PhosphoSite |
PhosphoSite-Q6P1X5
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TrEMBL |
A0A024R9E6
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UniProt Splice Variant |
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Entrez Gene |
6873
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UniGene |
Hs.604707
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RefSeq |
NP_003175
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HUGO |
HGNC:11536
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OMIM |
604912
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CCDS |
CCDS34937
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HPRD |
07060
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IMGT |
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EMBL |
AC021945
AC107960
AF026445
AF040701
AF057694
AK316592
BC035673
BC047732
BC064830
CH471060
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GenPept |
AAC02966
AAC13540
AAC68502
AAH35673
AAH47732
AAH64830
BAG38179
EAW91991
EAW91992
EAW91993
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