Version 5.4
Homo sapiens Protein: PLA2G12A
Summary
InnateDB Protein IDBP-33931.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2G12A
Protein Name phospholipase A2, group XIIA
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000243501
InnateDB Gene IDBG-33929 (PLA2G12A)
Protein Structure
UniProt Annotation
Function PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine. {ECO:0000269PubMed:12522102}.
Subcellular Localization Secreted {ECO:0000269PubMed:12522102}. Cytoplasm {ECO:0000269PubMed:12522102}.
Disease Associations
Tissue Specificity Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
GO:0047498 calcium-dependent phospholipase A2 activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0008150 biological_process
GO:0016042 lipid catabolic process
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005622 intracellular
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID
InterPro IPR010711 Phospholipase A2, group XII secretory
IPR016090 Phospholipase A2 domain
PFAM PF06951
PF00068
PRINTS
PIRSF
SMART SM00085
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BZM1
PhosphoSite PhosphoSite-
TrEMBL Q542Y6
UniProt Splice Variant
Entrez Gene 81579
UniGene Hs.389452
RefSeq NP_110448
HUGO HGNC:18554
OMIM 611652
CCDS CCDS3686
HPRD 17858
IMGT
EMBL AF306567 AF332892 AK075389 AK313081 AY359024 BC017218 CH471057
GenPept AAG50243 AAG50289 AAH17218 AAQ89383 BAC11589 BAG35907 EAX06247

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca