Version 5.4
Homo sapiens Protein: GAR1
Summary
InnateDB Protein IDBP-33997.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAR1
Protein Name GAR1 ribonucleoprotein homolog (yeast)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000226796
InnateDB Gene IDBG-33995 (GAR1)
Protein Structure
UniProt Annotation
Function Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO:0000269PubMed:10757788, ECO:0000269PubMed:15044956}.
Subcellular Localization Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005261 cation channel activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001522 pseudouridine synthesis
GO:0006364 rRNA processing
GO:0006812 cation transport
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0015030 Cajal body
GO:0031429 box H/ACA snoRNP complex
Protein Structure and Domains
PDB ID
InterPro IPR007504 H/ACA ribonucleoprotein complex, subunit Gar1/Naf1
IPR009000 Translation protein, beta-barrel domain
PFAM PF04410
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NY12
PhosphoSite PhosphoSite-Q9NY12
TrEMBL A0A024RDJ3
UniProt Splice Variant
Entrez Gene 54433
UniGene Hs.606828
RefSeq NP_061856
HUGO HGNC:14264
OMIM 606468
CCDS CCDS34050
HPRD 07569
IMGT
EMBL AJ276003 AY780787 BC003413 CH471057
GenPept AAH03413 AAV98357 CAB76563 EAX06253 EAX06254

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca