Version 5.4
Homo sapiens Protein: DSCC1
Summary
InnateDB Protein IDBP-34023.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DSCC1
Protein Name defective in sister chromatid cohesion 1 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000322180
InnateDB Gene IDBG-34021 (DSCC1)
Protein Structure
UniProt Annotation
Function Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3. {ECO:0000269PubMed:12766176, ECO:0000269PubMed:19907496}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006260 DNA replication
GO:0006275 regulation of DNA replication
GO:0034088 maintenance of mitotic sister chromatid cohesion
GO:0034421 post-translational protein acetylation
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID
InterPro IPR019128 Sister chromatid cohesion protein Dcc1
PFAM PF09724
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BVC3
PhosphoSite PhosphoSite-Q9BVC3
TrEMBL A0A024R9J7
UniProt Splice Variant
Entrez Gene 79075
UniGene Hs.700072
RefSeq NP_076999
HUGO HGNC:24453
OMIM 613203
CCDS CCDS6330
HPRD 13123
IMGT
EMBL AK054585 AY358866 BC001316 BC001531 CH471060
GenPept AAH01316 AAH01531 AAQ89225 BAB70767 EAW91994 EAW91995

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca