Version 5.4
Homo sapiens Protein: BRWD1
Summary
InnateDB Protein IDBP-3403.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRWD1
Protein Name bromodomain and WD repeat domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000342106
InnateDB Gene IDBG-3389 (BRWD1)
Protein Structure
UniProt Annotation
Function May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269PubMed:21834987}.
Subcellular Localization Cytoplasm. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:12359327}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007010 cytoskeleton organization
GO:0008360 regulation of cell shape
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NSI6
PhosphoSite PhosphoSite-Q9NSI6
TrEMBL
UniProt Splice Variant
Entrez Gene 54014
UniGene Hs.718269
RefSeq NP_001007247
HUGO HGNC:12760
OMIM
CCDS CCDS33557
HPRD 11683
IMGT
EMBL AB080586 AB080587 AF064861 AF129408 AJ222636 AJ238214 AJ292465 AJ292466 AK002177 AL163279 BC064602
GenPept AAH64602 BAD74071 BAD74072 CAA10896 CAB90452 CAC37033 CAC44371 CAC44372

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca