InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DEPTOR

Summary

InnateDB Protein

IDBP-34053.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DEPTOR

Protein Name

DEP domain containing MTOR-interacting protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000286234

InnateDB Gene

IDBG-34051 (DEPTOR)

Protein Structure

UniProt Annotation

Function

Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes. {ECO:0000269PubMed:19446321}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0032007	negative regulation of TOR signaling
GO:0035556	intracellular signal transduction
GO:0045792	negative regulation of cell size
GO:2001236	regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005622

intracellular

Protein Structure and Domains

PDB ID

InterPro

IPR000591 DEP domain
IPR001478 PDZ domain

PFAM

PF00610
PF00595
PF13180

PRINTS

PIRSF

SMART

SM00049
SM00228

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8TB45

PhosphoSite

PhosphoSite-Q8TB45

TrEMBL

UniProt Splice Variant

Entrez Gene

64798

UniGene

Hs.112981

RefSeq

NP_073620

HUGO

HGNC:22953

OMIM

612974

CCDS

CCDS6331

HPRD

13137

IMGT

EMBL

AC091563 AK022490 AK023916 AK297822 AK315175 AL136678 AP005717 BC012040 BC024746 CH471060

GenPept

AAH12040 AAH24746 BAB14054 BAB14723 BAG37616 BAG60159 CAB66613 EAW91997