Version 5.4
Homo sapiens Protein: LRRC17
Summary
InnateDB Protein IDBP-34064.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRC17
Protein Name leucine rich repeat containing 17
Synonyms P37NB;
Species Homo sapiens
Ensembl Protein ENSP00000249377
InnateDB Gene IDBG-34060 (LRRC17)
Protein Structure
UniProt Annotation
Function Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity). {ECO:0000250}.
Subcellular Localization Secreted, extracellular space {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in osteoblast cell lines. Well expressed in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung and only at the basal levels in the other tissues examined including adult kidney. More expressed in S-type neuroblastoma cells than in N-type neuroblastoma cells. {ECO:0000269PubMed:19336404, ECO:0000269PubMed:8982252}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045671 negative regulation of osteoclast differentiation
GO:0048539 bone marrow development
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N6Y2
PhosphoSite PhosphoSite-Q8N6Y2
TrEMBL C9JT74
UniProt Splice Variant
Entrez Gene 10234
UniGene Hs.567412
RefSeq NP_005815
HUGO HGNC:16895
OMIM
CCDS CCDS5727
HPRD 10059
IMGT
EMBL AC005250 AC073127 AY358889 BC027903 U32907
GenPept AAB41565 AAH27903 AAQ89248 AAS07483

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca