InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COL14A1

Summary

InnateDB Protein

IDBP-34094.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL14A1

Protein Name

collagen, type XIV, alpha 1

Synonyms

UND;

Species

Homo sapiens

Ensembl Protein

ENSP00000311809

InnateDB Gene

IDBG-34088 (COL14A1)

Protein Structure

UniProt Annotation

Function

Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250UniProtKB:P32018}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0030674	protein binding, bridging
GO:0044822	poly(A) RNA binding

Biological Process

GO:0016337	single organismal cell-cell adhesion
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030574	collagen catabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005581	collagen trimer
GO:0005596	collagen type XIV
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001791 Laminin G domain
IPR002035 von Willebrand factor, type A
IPR003961 Fibronectin, type III
IPR008160 Collagen triple helix repeat
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00054
PF02210
PF00092
PF00041
PF01108
PF01391

PRINTS

PIRSF

SMART

SM00210
SM00282
SM00327
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q05707