Version 5.4
Homo sapiens Protein: C12orf44
Summary
InnateDB Protein IDBP-34097.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C12orf44
Protein Name chromosome 12 open reading frame 44
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000338990
InnateDB Gene IDBG-34095 (C12orf44)
Protein Structure
UniProt Annotation
Function Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. {ECO:0000269PubMed:19287211, ECO:0000269PubMed:19597335}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:19597335}. Preautophagosomal structure {ECO:0000269PubMed:19597335}. Note=Under starvation conditions, it is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
Experimentally validated
Total 50 [view]
Protein-Protein 49 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0042802 identical protein binding
Biological Process
GO:0000045 autophagic vacuole assembly
Cellular Component
GO:0000407 pre-autophagosomal structure
Protein Structure and Domains
PDB ID
InterPro IPR012445 Autophagy-related protein 1010
PFAM PF07855
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BSB4
PhosphoSite PhosphoSite-Q9BSB4
TrEMBL H3BMZ4
UniProt Splice Variant
Entrez Gene 60673
UniGene
RefSeq NP_068753
HUGO HGNC:25679
OMIM 615089
CCDS CCDS8820
HPRD 08566
IMGT
EMBL AC025259 AF218031 AK021835 BC005151 BC009937 CH471111
GenPept AAG17273 AAH05151 AAH09937 BAB13907 EAW58229 EAW58230

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca