Version 5.4
Homo sapiens Protein: ADCY3
Summary
InnateDB Protein IDBP-34129.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADCY3
Protein Name adenylate cyclase 3
Synonyms AC3;
Species Homo sapiens
Ensembl Protein ENSP00000260600
InnateDB Gene IDBG-34125 (ADCY3)
Protein Structure
UniProt Annotation
Function Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004016 adenylate cyclase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0016849 phosphorus-oxygen lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0006171 cAMP biosynthetic process
GO:0006833 water transport
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0007608 sensory perception of smell
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009190 cyclic nucleotide biosynthetic process
GO:0034199 activation of protein kinase A activity
GO:0035556 intracellular signal transduction
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0055085 transmembrane transport
GO:0071377 cellular response to glucagon stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005929 cilium
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
IPR029787 Nucleotide cyclase
PFAM PF00211
PRINTS
PIRSF
SMART SM00044
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60266
PhosphoSite PhosphoSite-O60266
TrEMBL Q8NBM1
UniProt Splice Variant
Entrez Gene 109
UniGene Hs.681728
RefSeq NP_004027
HUGO HGNC:234
OMIM 600291
CCDS CCDS1715
HPRD 02620
IMGT
EMBL AB011083 AC012073 AF033861 AK075424 BC126235
GenPept AAD13403 AAI26236 AAY14787 BAA25437 BAC11613

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca