InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IMPDH2

Summary

InnateDB Protein

IDBP-34159.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IMPDH2

Protein Name

IMP (inosine 5'-monophosphate) dehydrogenase 2

Synonyms

IMPD2; IMPDH-II;

Species

Homo sapiens

Ensembl Protein

ENSP00000321584

InnateDB Gene

IDBG-34157 (IMPDH2)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03156, ECO:0000269PubMed:14766016}. Nucleus {ECO:0000255HAMAP- Rule:MF_03156, ECO:0000269PubMed:14766016}.

Disease Associations

Tissue Specificity

IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	39 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0003938	IMP dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0018580	nitronate monooxygenase activity
GO:0030554	adenyl nucleotide binding
GO:0046872	metal ion binding
GO:0047465	N-acylglucosamine-6-phosphate 2-epimerase activity

Biological Process

GO:0006051	N-acetylmannosamine metabolic process
GO:0006144	purine nucleobase metabolic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0046651	lymphocyte proliferation
GO:0051289	protein homotetramerization
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0060041	retina development in camera-type eye
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005778	peroxisomal membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000262 FMN-dependent dehydrogenase
IPR000644 CBS domain
IPR001093 IMP dehydrogenase/GMP reductase
IPR004136 2-nitropropane dioxygenase, NPD
IPR005990 Inosine-5\'-monophosphate dehydrogenase
IPR007260 Putative N-acetylmannosamine-6-phosphate epimerase

PFAM

PF01070
PF00571
PF00478
PF03060
PF04131

PRINTS

PIRSF

PIRSF000130

SMART

SM00116

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt