Version 5.4
Homo sapiens Protein: TRIM13
Summary
InnateDB Protein IDBP-34171.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM13
Protein Name tripartite motif containing 13
Synonyms CAR; DLEU5; LEU5; RFP2; RNF77;
Species Homo sapiens
Ensembl Protein ENSP00000367425
InnateDB Gene IDBG-34165 (TRIM13)
Protein Structure
UniProt Annotation
Function E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. {ECO:0000269PubMed:17314412, ECO:0000269PubMed:21333377, ECO:0000269PubMed:22178386}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:17314412, ECO:0000269PubMed:21333377, ECO:0000269PubMed:22178386}; Single-pass membrane protein {ECO:0000269PubMed:17314412, ECO:0000269PubMed:21333377, ECO:0000269PubMed:22178386}. Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID
InterPro IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF00643
PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00336
SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-O60858
TrEMBL X6RH27
UniProt Splice Variant
Entrez Gene 10206
UniGene Hs.713711
RefSeq
HUGO HGNC:9976
OMIM 605661
CCDS
HPRD 10414
IMGT
EMBL AL137060 AL391993
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca