Version 5.4
Homo sapiens Protein: KRT7
Summary
InnateDB Protein IDBP-34185.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT7
Protein Name keratin 7
Synonyms CK7; K2C7; K7; SCL;
Species Homo sapiens
Ensembl Protein ENSP00000329243
InnateDB Gene IDBG-34183 (KRT7)
Protein Structure
UniProt Annotation
Function Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). {ECO:0000269PubMed:10492017, ECO:0000269PubMed:12072504}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:2459129}.
Disease Associations
Tissue Specificity Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus. {ECO:0000269PubMed:12359226, ECO:0000269PubMed:2415537}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0016032 viral process
GO:0046417 chorismate metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0045095 keratin filament
Protein Structure and Domains
PDB ID
InterPro IPR001664 Intermediate filament protein
IPR003054 Keratin, type II
IPR009053 Prefoldin
IPR020822 Chorismate mutase, type II
PFAM PF00038
PF01817
PRINTS PR01276
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P08729
PhosphoSite PhosphoSite-P08729
TrEMBL
UniProt Splice Variant
Entrez Gene 3855
UniGene Hs.411501
RefSeq NP_005547
HUGO HGNC:6445
OMIM 148059
CCDS CCDS8822
HPRD 01014
IMGT
EMBL AC007338 AC007494 AF509887 AF509891 AF509892 AJ238246 BC002700 X03212 X13320 X13346 X13347 X13348 X13349 X13350 X13351 X13352 X13353
GenPept AAH02700 AAN64031 AAN64035 CAA26956 CAA31695 CAB41416

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca