InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AP1AR

Summary

InnateDB Protein

IDBP-34390.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP1AR

Protein Name

adaptor-related protein complex 1 associated regulatory protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000274000

InnateDB Gene

IDBG-34388 (AP1AR)

Protein Structure

UniProt Annotation

Function

Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus- end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo- lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. {ECO:0000269PubMed:15775984, ECO:0000269PubMed:19706427, ECO:0000269PubMed:21525240, ECO:0000269PubMed:22689987}.

Subcellular Localization

Golgi apparatus, trans-Golgi network. Late endosome. Early endosome. Note=Localizes to the juxta-nuclear Golgi region and to tubular structures throughout the cytoplasm, which are highly mobile and cycle between the juxta-nuclear area and the cell periphery.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019894	kinesin binding
GO:0035650	AP-1 adaptor complex binding

Biological Process

GO:0001920	negative regulation of receptor recycling
GO:0015031	protein transport
GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation
GO:0034613	cellular protein localization
GO:0048203	vesicle targeting, trans-Golgi to endosome
GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
GO:2000146	negative regulation of cell motility

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005794	Golgi apparatus
GO:0030133	transport vesicle