InnateDB Protein
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IDBP-34415.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SETD6
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Protein Name
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SET domain containing 6
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000219315
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InnateDB Gene
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IDBG-34413 (SETD6)
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Protein Structure
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Function |
Protein-lysine N-methyltransferase that specifically monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. {ECO:0000269PubMed:21131967}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:21131967}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
|
Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0018026
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peptidyl-lysine monomethylation
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GO:0032088
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negative regulation of NF-kappaB transcription factor activity
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GO:0050727
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regulation of inflammatory response
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Cellular Component |
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PDB ID |
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InterPro |
IPR001214
SET domain
IPR011383
RuBisCO-cytochrome methylase, RMS1
IPR015353
Rubisco LSMT, substrate-binding domain
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PFAM |
PF00856
PF09273
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PRINTS |
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PIRSF |
PIRSF011771
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SMART |
SM00317
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TBK2
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PhosphoSite |
PhosphoSite-Q8TBK2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
79918
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UniGene |
Hs.609248
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RefSeq |
NP_001153777
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HUGO |
HGNC:26116
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OMIM |
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CCDS |
CCDS54013
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HPRD |
07956
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IMGT |
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EMBL |
AC009118
AK024801
AK290495
BC022451
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GenPept |
AAH22451
BAB15011
BAF83184
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