Version 5.4
Homo sapiens Protein: SETD6
Summary
InnateDB Protein IDBP-34417.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SETD6
Protein Name SET domain containing 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000310082
InnateDB Gene IDBG-34413 (SETD6)
Protein Structure
UniProt Annotation
Function Protein-lysine N-methyltransferase that specifically monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. {ECO:0000269PubMed:21131967}.
Subcellular Localization Nucleus {ECO:0000269PubMed:21131967}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016279 protein-lysine N-methyltransferase activity
GO:0051059 NF-kappaB binding
Biological Process
GO:0018026 peptidyl-lysine monomethylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0050727 regulation of inflammatory response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001214 SET domain
IPR011383 RuBisCO-cytochrome methylase, RMS1
IPR015353 Rubisco LSMT, substrate-binding domain
PFAM PF00856
PF09273
PRINTS
PIRSF PIRSF011771
SMART SM00317
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TBK2
PhosphoSite PhosphoSite-Q8TBK2
TrEMBL B4E3Q8
UniProt Splice Variant
Entrez Gene 79918
UniGene Hs.609248
RefSeq NP_079136
HUGO HGNC:26116
OMIM
CCDS CCDS10798
HPRD 07956
IMGT
EMBL AC009118 AK024801 AK290495 AK304822 BC022451
GenPept AAH22451 BAB15011 BAF83184 BAG65570

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca