Version 5.4
Homo sapiens Protein: MRGPRX4
Summary
InnateDB Protein IDBP-34562.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRGPRX4
Protein Name MAS-related GPR, member X4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000314042
InnateDB Gene IDBG-34560 (MRGPRX4)
Protein Structure
UniProt Annotation
Function Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. {ECO:0000269PubMed:11850634}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96LA9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 117196
UniGene Hs.632138
RefSeq NP_473373
HUGO HGNC:17617
OMIM 607230
CCDS CCDS7831
HPRD 06249
IMGT
EMBL AC090099 AF474991 AF474992 AY042216 BC095509 BC107099 BC107100
GenPept AAH95509 AAI07100 AAI07101 AAK91807 AAL86882 AAL86883

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca