Version 5.4
Homo sapiens Protein: SAA1
Summary
InnateDB Protein IDBP-34661.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SAA1
Protein Name serum amyloid A1
Synonyms PIG4; SAA; SAA2; TP53I4;
Species Homo sapiens
Ensembl Protein ENSP00000348918
InnateDB Gene IDBG-34659 (SAA1)
Protein Structure
UniProt Annotation
Function Major acute phase protein.
Subcellular Localization Secreted {ECO:0000269PubMed:7115671}.
Disease Associations Note=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. {ECO:0000269PubMed:1463770}.Note=Elevated serum SAA1 protein levels may be associated with lung cancer. {ECO:0000269PubMed:1463770}.
Tissue Specificity Expressed by the liver; secreted in plasma (at protein level). {ECO:0000269PubMed:12973732, ECO:0000269PubMed:4816450, ECO:0000269PubMed:7115671}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0008201 heparin binding
Biological Process
GO:0006953 acute-phase response
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0030168 platelet activation
GO:0030593 neutrophil chemotaxis
GO:0045087 innate immune response
GO:0045785 positive regulation of cell adhesion
GO:0048246 macrophage chemotaxis
GO:0048247 lymphocyte chemotaxis
GO:0050708 regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0050716 positive regulation of interleukin-1 secretion
GO:0050728 negative regulation of inflammatory response
Cellular Component
GO:0005576 extracellular region
GO:0034364 high-density lipoprotein particle
GO:0070062 extracellular vesicular exosome
GO:0071682 endocytic vesicle lumen
Protein Structure and Domains
PDB ID
InterPro IPR000096 Serum amyloid A protein
PFAM PF00277
PRINTS PR00306
PIRSF PIRSF002472
SMART SM00197
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P0DJI8
PhosphoSite PhosphoSite-P0DJI8
TrEMBL E9PQD6
UniProt Splice Variant
Entrez Gene 6288
UniGene
RefSeq NP_954630
HUGO HGNC:10513
OMIM 104750
CCDS CCDS7835
HPRD 00097
IMGT
EMBL AC107948 BC007022 BC105796 CR542241 M10906 M23698 X51439 X51441 X51442 X56652
GenPept AAA60297 AAA64799 AAH07022 AAI05797 CAA35804 CAA35806 CAA35807 CAA39974 CAG47037

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca