Version 5.4
Homo sapiens Protein: ATAD2
Summary
InnateDB Protein IDBP-34696.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATAD2
Protein Name ATPase family, AAA domain containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000287394
InnateDB Gene IDBG-34694 (ATAD2)
Protein Structure
UniProt Annotation
Function May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. {ECO:0000269PubMed:17998543}.
Subcellular Localization Nucleus {ECO:0000269PubMed:17998543}.
Disease Associations
Tissue Specificity Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors. {ECO:0000269PubMed:15721472, ECO:0000269PubMed:17076897, ECO:0000269PubMed:17660802}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006351 transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001487 Bromodomain
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00439
PF00004
PF07724
PF13304
PRINTS PR00503
PIRSF
SMART SM00297
SM00382
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PL18
PhosphoSite PhosphoSite-Q6PL18
TrEMBL A0A024R9G7
UniProt Splice Variant
Entrez Gene 29028
UniGene Hs.370834
RefSeq NP_054828
HUGO HGNC:30123
OMIM 611941
CCDS CCDS6343
HPRD 10678
IMGT
EMBL AF118088 AK097133 AL833653 AY598335 BC010686 BC019909 BC113656 CH471060 CR749832
GenPept AAF22032 AAH10686 AAH19909 AAI13657 AAT06746 BAC04959 CAH18688 CAH56229 EAW92035 EAW92036

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca