Version 5.4
Homo sapiens Protein: TCTA
Summary
InnateDB Protein IDBP-34811.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCTA
Protein Name T-cell leukemia translocation altered gene
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000273590
InnateDB Gene IDBG-34809 (TCTA)
Protein Structure
UniProt Annotation
Function May be required for cellular fusion during osteoclastogenesis. {ECO:0000269PubMed:19560569}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations Note=A chromosomal aberration involving TCTA is associated with T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(1;3)(p34;p21).
Tissue Specificity Ubiquitous. Highest level of expression in kidney. Present in monocytes, osteoclasts, macrophages, synoviocytes and synovial lining cells (at protein level). {ECO:0000269PubMed:7728759}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR016560 T-cell leukemia translocation-altered gene protein
PFAM PF15128
PRINTS
PIRSF PIRSF009935
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P57738
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 6988
UniGene Hs.739127
RefSeq NP_071503
HUGO HGNC:11692
OMIM 600690
CCDS CCDS2796
HPRD 15977
IMGT
EMBL AC104452 AK311839 BC005157 CR457411 L41143
GenPept AAA97514 AAH05157 BAG34781 CAG33692

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca