Version 5.4
Homo sapiens Protein: RHBDD3
Summary
InnateDB Protein IDBP-3484.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHBDD3
Protein Name rhomboid domain containing 3
Synonyms C22orf3; HS984G1A; PTAG;
Species Homo sapiens
Ensembl Protein ENSP00000216085
InnateDB Gene IDBG-3482 (RHBDD3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
Biological Process
GO:0000165 MAPK cascade
GO:0001889 liver development
GO:0002673 regulation of acute inflammatory response
GO:0006508 proteolysis
GO:0009410 response to xenobiotic stimulus
GO:0032815 negative regulation of natural killer cell activation
GO:0045732 positive regulation of protein catabolic process
GO:0050708 regulation of protein secretion
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR009060 UBA-like
IPR022764 Peptidase S54, rhomboid domain
PFAM PF01694
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y3P4
PhosphoSite PhosphoSite-Q9Y3P4
TrEMBL B0QYJ2
UniProt Splice Variant
Entrez Gene 25807
UniGene Hs.106730
RefSeq NP_036397
HUGO HGNC:1308
OMIM
CCDS CCDS13850
HPRD 12800
IMGT
EMBL AL031186 AL050346 BC002705 CH471095 CR456411 CR457382
GenPept AAH02705 CAB43551 CAG30297 CAG33663 CAI18000 EAW59778 EAW59779

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca