InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LNPEP

Summary

InnateDB Protein

IDBP-34886.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LNPEP

Protein Name

leucyl/cystinyl aminopeptidase

Synonyms

CAP; IRAP; P-LAP; PLAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000231368

InnateDB Gene

IDBG-34882 (LNPEP)

Protein Structure

UniProt Annotation

Function

Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. {ECO:0000269PubMed:11389728, ECO:0000269PubMed:11707427, ECO:0000269PubMed:1731608}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11389728}; Single-pass type II membrane protein {ECO:0000269PubMed:11389728}. Note=In brain only the membrane- bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.Leucyl-cystinyl aminopeptidase, pregnancy serum form: Secreted. Note=During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.

Disease Associations

Tissue Specificity

Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon. {ECO:0000269PubMed:11389728, ECO:0000269PubMed:8550619, ECO:0000269PubMed:9177475}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	11 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0006508	proteolysis
GO:0007267	cell-cell signaling
GO:0007565	female pregnancy
GO:0030163	protein catabolic process
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0061024	membrane organization

Cellular Component

GO:0005576	extracellular region
GO:0005622	intracellular
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0031905	early endosome lumen
GO:0048471	perinuclear region of cytoplasm