InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TSG101

Summary

InnateDB Protein

IDBP-35024.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TSG101

Protein Name

tumor susceptibility gene 101

Synonyms

TSG10; VPS23;

Species

Homo sapiens

Ensembl Protein

ENSP00000251968

InnateDB Gene

IDBG-35022 (TSG101)

Protein Structure

UniProt Annotation

Function

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. {ECO:0000269PubMed:11916981, ECO:0000269PubMed:17556548, ECO:0000269PubMed:17853893, ECO:0000269PubMed:21070952, ECO:0000269PubMed:21757351}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane; Peripheral membrane protein. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis.

Disease Associations

Tissue Specificity

Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	149 [view]
Protein-Protein	146 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity
GO:0043130	ubiquitin binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006464	cellular protein modification process
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0015031	protein transport
GO:0016032	viral process
GO:0016197	endosomal transport
GO:0019058	viral life cycle
GO:0019068	virion assembly
GO:0019082	viral protein processing
GO:0030154	cell differentiation
GO:0030216	keratinocyte differentiation
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046755	non-lytic virus budding
GO:0051301	cell division
GO:0061024	membrane organization
GO:0075733	intracellular transport of virus

Cellular Component

GO:0000813	ESCRT I complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome