InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TPM4

Summary

InnateDB Protein

IDBP-35243.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPM4

Protein Name

tropomyosin 4

Synonyms

HEL-S-108;

Species

Homo sapiens

Ensembl Protein

ENSP00000345230

InnateDB Gene

IDBG-35241 (TPM4)

Protein Structure

UniProt Annotation

Function

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. {ECO:0000269PubMed:1836432}.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level). {ECO:0000269PubMed:1836432}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.

Experimentally validated
Total	47 [view]
Protein-Protein	47 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0008307	structural constituent of muscle

Biological Process

GO:0001649	osteoblast differentiation
GO:0006928	cellular component movement
GO:0006936	muscle contraction
GO:0030049	muscle filament sliding

Cellular Component

GO:0001725	stress fiber
GO:0002102	podosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005862	muscle thin filament tropomyosin
GO:0016020	membrane
GO:0030863	cortical cytoskeleton
GO:0031941	filamentous actin
GO:0070062	extracellular vesicular exosome