InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NDST3

Summary

InnateDB Protein

IDBP-35343.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDST3

Protein Name

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

Synonyms

HSST3;

Species

Homo sapiens

Ensembl Protein

ENSP00000296499

InnateDB Gene

IDBG-35341 (NDST3)

Protein Structure

UniProt Annotation

Function

Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity. {ECO:0000269PubMed:9915799}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, kidney, liver, fetal and adult lung, adult pancreas, placenta, fetal spleen and fetal thymus. Not detected in adult/ fetal heart and skeletal muscle. {ECO:0000269PubMed:9915799}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity
GO:0016787	hydrolase activity
GO:0019213	deacetylase activity