InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NSMCE2

Summary

InnateDB Protein

IDBP-35366.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NSMCE2

Protein Name

non-SMC element 2, MMS21 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000287437

InnateDB Gene

IDBG-35364 (NSMCE2)

Protein Structure

UniProt Annotation

Function

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression. {ECO:0000269PubMed:16055714, ECO:0000269PubMed:16810316, ECO:0000269PubMed:17589526, ECO:0000269PubMed:19502785}.

Subcellular Localization

Nucleus. Chromosome, telomere. Note=Localizes to PML nuclear bodies in ALT cell lines.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019789	SUMO ligase activity

Biological Process

GO:0000722	telomere maintenance via recombination
GO:0000724	double-strand break repair via homologous recombination
GO:0007067	mitotic nuclear division
GO:0016925	protein sumoylation
GO:0034184	positive regulation of maintenance of mitotic sister chromatid cohesion
GO:0045842	positive regulation of mitotic metaphase/anaphase transition
GO:0090398	cellular senescence