Version 5.4
Homo sapiens Protein: MRGPRX1
Summary
InnateDB Protein IDBP-35379.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRGPRX1
Protein Name MAS-related GPR, member X1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000305766
InnateDB Gene IDBG-35377 (MRGPRX1)
Protein Structure
UniProt Annotation
Function Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in a histamine-independent manner. {ECO:0000269PubMed:11850634, ECO:0000269PubMed:20004959}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. {ECO:0000269PubMed:11850634}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0006953 acute-phase response
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96LB2
PhosphoSite PhosphoSite-Q96LB2
TrEMBL W8W3P5
UniProt Splice Variant
Entrez Gene 259249
UniGene Hs.711459
RefSeq NP_671732
HUGO HGNC:17962
OMIM 607227
CCDS CCDS7846
HPRD 06246
IMGT
EMBL AB065846 AB083628 AC023078 AF474989 AF474990 AY042213 BC096835 CH471064 HG426070
GenPept AAH96835 AAK91804 AAL86880 AAL86881 BAB89341 BAC06064 CDG86188 EAW68360

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca