InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EPT1

Summary

InnateDB Protein

IDBP-35565.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPT1

Protein Name

ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000260585

InnateDB Gene

IDBG-35563 (EPT1)

Protein Structure

UniProt Annotation

Function

Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via 'Kennedy' pathway.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed. Abundant in brain, placenta, liver and pancreas, followed by heart, skeletal muscle, lung and kidney. In brain it is strongly expressed in cerebellum, followed by the occipital pole and the frontal lobe. {ECO:0000269PubMed:17132865}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004307	ethanolaminephosphotransferase activity
GO:0016780	phosphotransferase activity, for other substituted phosphate groups
GO:0046872	metal ion binding

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006646	phosphatidylethanolamine biosynthetic process
GO:0008654	phospholipid biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process