InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUS4L

Summary

InnateDB Protein

IDBP-35592.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUS4L

Protein Name

dihydrouridine synthase 4-like (S. cerevisiae)

Synonyms

DUS4; PP35;

Species

Homo sapiens

Ensembl Protein

ENSP00000265720

InnateDB Gene

IDBG-35590 (DUS4L)

Protein Structure

UniProt Annotation

Function

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0017150	tRNA dihydrouridine synthase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0002943	tRNA dihydrouridine synthesis
GO:0008033	tRNA processing
GO:0055114	oxidation-reduction process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal
IPR001269 tRNA-dihydrouridine synthase

PFAM

PF00724
PF01207

PRINTS

PIRSF

PIRSF006621

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95620

PhosphoSite

PhosphoSite-O95620

TrEMBL

F8WEL2

UniProt Splice Variant

Entrez Gene

11062

UniGene

Hs.97627

RefSeq

NP_853559

HUGO

HGNC:21517

OMIM

CCDS

CCDS5745

HPRD

17886

IMGT

EMBL

AC002381 AC004839 AK294095 AK297195 BC111774 CH236947 CH471070 U62767

GenPept

AAD00100 AAI11775 BAG57433 BAG59682 EAL24391 EAW83400 EAW83401 EAW83402 EAW83403 EAW83404