InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOAT2

Summary

InnateDB Protein

IDBP-35817.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOAT2

Protein Name

sterol O-acyltransferase 2

Synonyms

ACACT2; ACAT2; ARGP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000301466

InnateDB Gene

IDBG-35815 (SOAT2)

Protein Structure

UniProt Annotation

Function

Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0004772	sterol O-acyltransferase activity
GO:0015485	cholesterol binding
GO:0016746	transferase activity, transferring acyl groups
GO:0034736	cholesterol O-acyltransferase activity

Biological Process

GO:0008203	cholesterol metabolic process
GO:0010742	macrophage derived foam cell differentiation
GO:0030299	intestinal cholesterol absorption
GO:0033344	cholesterol efflux
GO:0034379	very-low-density lipoprotein particle assembly
GO:0034435	cholesterol esterification
GO:0042632	cholesterol homeostasis

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005903	brush border
GO:0016020	membrane
GO:0016021	integral component of membrane