InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SIN3B

Summary

InnateDB Protein

IDBP-35829.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIN3B

Protein Name

SIN3 homolog B, transcription regulator (yeast)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000369131

InnateDB Gene

IDBG-35825 (SIN3B)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00810}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	50 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007519	skeletal muscle tissue development
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048511	rhythmic process
GO:0048738	cardiac muscle tissue development