InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRMT3

Summary

InnateDB Protein

IDBP-35894.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRMT3

Protein Name

protein arginine methyltransferase 3

Synonyms

HRMT1L3;

Species

Homo sapiens

Ensembl Protein

ENSP00000331879

InnateDB Gene

IDBG-35890 (PRMT3)

Protein Structure

UniProt Annotation

Function

Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0016274	protein-arginine N-methyltransferase activity
GO:0016740	transferase activity
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0046872	metal ion binding
GO:0072341	modified amino acid binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0008152	metabolic process
GO:0018216	peptidyl-arginine methylation
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0031397	negative regulation of protein ubiquitination
GO:0034969	histone arginine methylation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome

Protein Structure and Domains

PDB ID

InterPro

IPR003402 tRNA transferase Trm5/Tyw2
IPR007848 Methyltransferase small domain
IPR010456 Ribosomal L11 methyltransferase, PrmA
IPR013216 Methyltransferase type 11
IPR025799 Protein arginine N-methyltransferase
IPR027555 tRNA (mo5U34)-methyltransferase-like
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF02475
PF05175
PF06325
PF08241
PF05185
PF08003

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O60678

PhosphoSite