InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNK3

Summary

InnateDB Protein

IDBP-35979.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNK3

Protein Name

potassium channel, subfamily K, member 3

Synonyms

K2p3.1; OAT1; PPH4; TASK; TASK-1; TBAK1;

Species

Homo sapiens

Ensembl Protein

ENSP00000306275

InnateDB Gene

IDBG-35977 (KCNK3)

Protein Structure

UniProt Annotation

Function

pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. {ECO:0000269PubMed:9312005}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Pulmonary hypertension, primary, 4 (PPH4) [MIM:615344]: A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs. {ECO:0000269PubMed:23883380}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005252	open rectifier potassium channel activity
GO:0005267	potassium channel activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0022841	potassium ion leak channel activity
GO:0042803	protein homodimerization activity
GO:0044548	S100 protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0007420	brain development
GO:0034220	ion transmembrane transport
GO:0034765	regulation of ion transmembrane transport
GO:0042493	response to drug
GO:0051481	negative regulation of cytosolic calcium ion concentration
GO:0071294	cellular response to zinc ion
GO:0071456	cellular response to hypoxia
GO:0071805	potassium ion transmembrane transport
GO:0090102	cochlea development

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003092 Two pore domain potassium channel, TASK family
IPR003280 Two pore domain potassium channel
IPR005406 Potassium channel subfamily K member 3
IPR013099 Two pore domain potassium channel domain

PFAM

PF07885

PRINTS

PR01095
PR01333
PR01584

PIRSF

PIRSF038061

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt